Scholars Week is a week-long showcase of academic pursuits and research among the academic departments. The week culminates in a university-wide Scholars Day Exposition held on the campus at Middle Tennessee State University. This event covers the scholarship conducted during the fall and spring semesters.
Scholars Day showcases the same academic rigor as Scholars Week, but instead is a one day event showcasing the academic pursuits and research during the summer semester.
(Middle Tennessee State University, 2018)
Morton, S. P.; Phillips, J. B.; Phillips, J. L.
Abstract Research in the field of HIV transmission has yet to provide a vaccine for the imponderable virus. Though progress has been made to extend the life of those chronically infected, a solution to the transmission of the disease outside of abstinence is still no where to be found. Previous laboratory studies involving electrostatic surface charge analysis revealed the sensitivity of gp120 to changes in pH across levels consistent with those found in the human body. A prototype computational approach was developed and found to agree with laboratory results. We previously refined the process and utilized additional methods to determine a system capable of classifying Env structures through machine learning techniques. We have expounded upon the analytical procedure to encompass the residue level and expanded the process to include minimization steps to ensure the integrity of the protein structures. Additionally, the process has been enhanced with advanced data compression techniques to allow for more in depth analysis of the systems. In this research we continue to validate previous work in several studies as well as increase the returned knowledge through a new technique that reveals what we hypothesize to be the mechanistic residues responsible for the binding process.