SYNTHESIS OF PEPTOID SUBMONOMER MIMICS OF ARGININE

Abstract

Peptides identified through natural product or high-throughput screening are becoming attractive therapeutics. However, many potential peptide therapeutics have poor proteolytic stability and short in vivo half-lives. To address these issues, many researchers use peptoid compounds, which are peptide mimics, as therapeutics. Because they are completely resistant to proteolysis, peptoids make excellent candidates for a range of different biomedical applications. The present study supports the growing field of research into peptoid therapeutics by developing peptoid submonomer mimics of common amino acids. The peptide that was used in this research is the affinity tag AviD, which has unique amino acids that can be studied by peptoid submonomer substitution. The main focus of this work is on arginine. The overall goal of this study is to determine which peptoid submonomer best mimics these amino acids and maintains peptomer secondary structure in AviD. The present research will aid researchers in developing peptoid mimics of useful peptide therapeutics.