Considering the importance of 2-Amino-3-cyano-4H-pyran derivatives and the need for the development of new environmental friendly synthetic methodologies, the combination of Multicomponent Coupling reactions (MCR) and Deep Eutectic solvents (DES) was the goal of our study in order to make the reaction more environmentally, as well as economically, viable. Moreover, a simple work up procedure was developed via recrystallization from ethanol or ethanol-water to avoid the use of expensive silica gel chromatography and exclude the massive use of organic chromatography eluents. Finally, this work avoids the use of toxic and expensive catalyst or solvents.