Influence of long-term furosemide use on bone mineral content, bone metabolism markers, and weight loss in horses

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Pritchard, Abby
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Middle Tennessee State University
Furosemide is a diuretic commonly used to reduce the incidence of exercise induced pulmonary hemorrhage (EIPH) in racehorses. Previous research suggests furosemide negatively influences calcium balance and may have long-term implications for bone health. In this study, furosemide use was evaluated over 56d for effect on bone mineral content (BMC), bone metabolism markers osteocalcin (OC) and pyridinoline cross-links (PYD) and weight loss post administration. No treatment effects were observed for BMC, but there was a period effect across all bone cortices (p<0.0001). OC showed no difference between groups (P=0.26) or days (P=0.25). PYD tended to be lower in FUR (P=0.0584) and exhibited a day effect (P<0.0001). Body weight change indicated day by time (P=0.0001), treatment by time (P<0.0001), and day by treatment (P<0.0001) interactions. While there was no treatment effect on BMC, the trend toward lower PYD in FUR may warrant further investigation with different times and imaging techniques.
Bone metabolism, Bone mineral content, Furosemide, Horse, Weight loss