A Computational Electrostatic Modeling Pipeline for Comparing pH-dependent gp120-CD4 Interactions in Founder and Chronic HIV Strains

dc.contributor.advisorPhillips, Joshua
dc.contributor.authorHowton, Jonathan
dc.contributor.committeememberBarbosa, Sal
dc.contributor.committeememberWright, Stephen
dc.contributor.departmentComputer Scienceen_US
dc.date.accessioned2017-05-26T18:00:55Z
dc.date.available2017-05-26T18:00:55Z
dc.date.issued2017-03-24
dc.description.abstractThough Human Immunodeficiency Virus has been studied for several decades, a consistently
dc.description.abstracteffective vaccine has not yet been produced. While most experimental and computational
dc.description.abstractwork in this area has been performed under slightly basic conditions (eg. blood/-
dc.description.abstractplasma), the viral transmission event generally occurs at the highly acidic mucosa. Since
dc.description.abstractpH can greatly affect protein structure, it likely affects epitope exposure to either inhibit or
dc.description.abstractfacilitate transmission. In this thesis, a pipeline for analyzing the pH sensitivity of proteinprotein
dc.description.abstractinteractions is applied to the transmission critical interaction between the HIV gp120
dc.description.abstractand host CD4 proteins. The interaction between gp120 and CD4 is shown to be stronger
dc.description.abstractat low pH for all strains tested, which is consistent with previous work and supports the
dc.description.abstractaccuracy of the introduced pipeline. Also, early transmitted founder (TF) strains generally
dc.description.abstractbind CD4 better at low pH and are more pH sensitive than systemically circulating chronic
dc.description.abstractcontrol (CC) strains.
dc.description.degreeM.S.
dc.identifier.urihttp://jewlscholar.mtsu.edu/xmlui/handle/mtsu/5324
dc.publisherMiddle Tennessee State University
dc.subjectComputational
dc.subjectHIV
dc.subjectModeling
dc.subjectPH
dc.subjectProtein
dc.subjectVirus
dc.subject.umiComputer science
dc.subject.umiBioinformatics
dc.subject.umiVirology
dc.thesis.degreegrantorMiddle Tennessee State University
dc.thesis.degreelevelMasters
dc.titleA Computational Electrostatic Modeling Pipeline for Comparing pH-dependent gp120-CD4 Interactions in Founder and Chronic HIV Strains
dc.typeThesis

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