Differentiation Paradigms and STAT Protein Expression in Neuro-2A Cells

dc.contributor.advisor Stewart, William en_US
dc.contributor.author Keating, Cody E. en_US
dc.contributor.committeemember Elrod-Erickson, Matthew en_US
dc.contributor.committeemember Farone, Anthony en_US
dc.contributor.department Biology en_US
dc.date.accessioned 2014-06-02T18:51:31Z
dc.date.available 2014-06-02T18:51:31Z
dc.date.issued 2013-08-16 en_US
dc.description.abstract One of the most recent and exciting potential treatments for cancer is differentiation therapy which is inducing the differentiation of cancerous cells into normal functioning somatic cells. An excellent candidate for differentiation therapy is the neuroblastoma. The compounds examined in this experiment to induce differentiation in the N2A murine neuroblastoma cell line while performing morphometrics and western blot analysis in this project are: mevinolin, dibutyryl cAMP, all-trans-retinoic acid, ceramide, and perillyl alcohol. Morphometric study data: 12h study, perillyl alcohol exhibited the greatest differentiation at 63%; 24h study, perillyl alcohol exhibited the greatest again at 62%; 48h study, perillyl alcohol was again the highest differentiator, but this time at 68% differentiation. STAT proteins were found to be expressed in all treatments. Acetylcholinesterase was expressed in most of the treatments. NeuN was present in all treatments. en_US
dc.description.degree M.S. en_US
dc.identifier.uri http://jewlscholar.mtsu.edu/handle/mtsu/3576
dc.publisher Middle Tennessee State University en_US
dc.subject Differentiation en_US
dc.subject JAK en_US
dc.subject Morphometric en_US
dc.subject Neurobiology en_US
dc.subject Neuroblastoma en_US
dc.subject STAT en_US
dc.subject.umi Molecular biology en_US
dc.subject.umi Biology en_US
dc.thesis.degreegrantor Middle Tennessee State University en_US
dc.thesis.degreelevel Masters en_US
dc.title Differentiation Paradigms and STAT Protein Expression in Neuro-2A Cells en_US
dc.type Thesis en_US
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