ISOLATION AND ANALYSIS OF COMPOUNDS WITH ANTI-TRYPANOSOMAL AND ANTI-CANCER ACTIVITY

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dc.contributor.advisorDunlap, Norma
dc.contributor.authorLiyana Pathiranage, Anuradha
dc.contributor.committeememberHandy, Scott
dc.contributor.committeememberDing, Keying
dc.contributor.committeememberAltman, Elliot
dc.contributor.committeememberFarone, Mary
dc.contributor.departmentChemistryen_US
dc.date.accessioned2016-08-15T15:03:29Z
dc.date.available2016-08-15T15:03:29Z
dc.date.issued2016-07-31
dc.description.abstractABSTRACT
dc.description.abstractISOLATION AND ANALYSIS OF COMPOUNDS WITH ANTI-TRYPANOSOMAL AND ANTI-CANCER ACTIVITY
dc.description.abstractAnuradha Liyana Pathiranage
dc.description.abstractProject 1
dc.description.abstractSynthesis and evaluation of ether-linked demethylepipodophyllotoxin dimers.
dc.description.abstractA series of novel ether-linked dimers of demethylepipodophyllotoxin are topoisomerase II poisons that exhibit higher levels of double-stranded versus single-stranded DNA cleavage than their corresponding monomers. The dimers also have higher levels of tumor cell cytotoxicity than the monomers, lending support to the two-drug model for interaction of demethylepipodophyllotoxins with human topoisomerase IIα.
dc.description.abstractProject 2
dc.description.abstractAntitrypanosomal activity of iridals from Iris domestica.
dc.description.abstractThe petroleum ether extract of Iris domestica (Belamcanda chinensis) has been evaluated for activity against Trypanosoma brucei. Bioassay-guided fractionation led to the isolation of four known iridals as the active components. Chemical modification of these isolates afforded novel stable derivatives that maintained bioactivity. This is the first known report of the antitrypanosomal activity of these compounds.
dc.description.degreePh.D.
dc.identifier.urihttp://jewlscholar.mtsu.edu/handle/mtsu/4977
dc.publisherMiddle Tennessee State University
dc.subject.umiChemistry
dc.thesis.degreegrantorMiddle Tennessee State University
dc.thesis.degreelevelDoctoral
dc.titleISOLATION AND ANALYSIS OF COMPOUNDS WITH ANTI-TRYPANOSOMAL AND ANTI-CANCER ACTIVITY
dc.typeDissertation

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