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Direct laser trapping for measuring the behavior of transfused erythrocytes in a sickle cell anemia patient

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dc.contributor Middle Tennessee State University. Physics and Astronomy Department. en_US Pellizzaro, Aline en_US Welker, Gabriel en_US Scott, David en_US Solomon, Rance en_US Cooper, James en_US Farone, Anthony en_US Farone, Mary en_US Mushi, Robert S. en_US Aguinaga, Maria del Pilar en_US Erenso, Daniel en_US 2014-06-24T15:41:58Z 2014-06-24T15:41:58Z 2012-08-16 en_US
dc.identifier.citation Biomedical Optics Express. 2012 Aug 16;3(9):2190 en_US
dc.description.abstract Using a laser trap, we have studied the properties of erythrocytes from a sickle cell anemia patient (SCA) after receiving an intravenous blood transfusion, and a normal adult individual carrying normal adult hemoglobin. The hemoglobin type and quantitation assessment was carried out by high performance liquid chromatography (HPLC). We conducted an analysis of the size distributions of the cells. By targeting those erythrocytes in the overlapping regions of size distributions, we have investigated their properties when the cells are trapped and released. The efficacy of the transfusion treatment is also studied by comparing the relative changes in deformation and the relaxation-time of the cells in the two samples. en_US
dc.rights This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. en_US
dc.subject Experimental physics en_US
dc.subject Biology and medicine en_US
dc.subject Optical confinement and manipulation en_US
dc.subject Optical tweezers or optical manipulation en_US
dc.title Direct laser trapping for measuring the behavior of transfused erythrocytes in a sickle cell anemia patient en_US
dc.type Research Article en_US

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