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ISOLATION AND ANALYSIS OF COMPOUNDS WITH ANTI-TRYPANOSOMAL AND ANTI-CANCER ACTIVITY

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dc.contributor.advisor Dunlap, Norma
dc.contributor.author Liyana Pathiranage, Anuradha
dc.date.accessioned 2016-08-15T15:03:29Z
dc.date.available 2016-08-15T15:03:29Z
dc.date.issued 2016-07-31
dc.identifier.uri http://jewlscholar.mtsu.edu/handle/mtsu/4977
dc.description.abstract ABSTRACT
dc.description.abstract ISOLATION AND ANALYSIS OF COMPOUNDS WITH ANTI-TRYPANOSOMAL AND ANTI-CANCER ACTIVITY
dc.description.abstract Anuradha Liyana Pathiranage
dc.description.abstract Project 1
dc.description.abstract Synthesis and evaluation of ether-linked demethylepipodophyllotoxin dimers.
dc.description.abstract A series of novel ether-linked dimers of demethylepipodophyllotoxin are topoisomerase II poisons that exhibit higher levels of double-stranded versus single-stranded DNA cleavage than their corresponding monomers. The dimers also have higher levels of tumor cell cytotoxicity than the monomers, lending support to the two-drug model for interaction of demethylepipodophyllotoxins with human topoisomerase IIα.
dc.description.abstract Project 2
dc.description.abstract Antitrypanosomal activity of iridals from Iris domestica.
dc.description.abstract The petroleum ether extract of Iris domestica (Belamcanda chinensis) has been evaluated for activity against Trypanosoma brucei. Bioassay-guided fractionation led to the isolation of four known iridals as the active components. Chemical modification of these isolates afforded novel stable derivatives that maintained bioactivity. This is the first known report of the antitrypanosomal activity of these compounds.
dc.publisher Middle Tennessee State University
dc.title ISOLATION AND ANALYSIS OF COMPOUNDS WITH ANTI-TRYPANOSOMAL AND ANTI-CANCER ACTIVITY
dc.type Dissertation
dc.contributor.committeemember Handy, Scott
dc.contributor.committeemember Ding, Keying
dc.contributor.committeemember Altman, Elliot
dc.contributor.committeemember Farone, Mary
dc.thesis.degreelevel Doctoral
dc.thesis.degreegrantor Middle Tennessee State University
dc.subject.umi Chemistry
dc.description.degree Ph.D.
dc.contributor.department Chemistry en_US


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