Isolation and Identification of Medicinal Metabolites from Cichorium intybus
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Authors
Journal Title
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Volume Title
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University Honors College, Middle Tennessee State University
Abstract
Cichorium
intybus
(Chicory)
has
been
used
medicinally
by
a
variety
of
cultures
dating
back
thousands
of
years.
Historically,
it
has
been
most
commonly
used
as
a
diuretic,
a
hepatoprotective
agent,
and
an
anti-‐inflammatory
agent
as
well
as
being
a
popular
additive
in
coffee.
Some
of
the
compounds
linked
to
the
observed
medicinal
properties
of
chicory
are
β-‐sitosterol
(wound
healing),
8-‐deoxylactucin
(anthelmintic
and
anti-‐inflammatory),
and
cichoric
acid
(anti-‐viral).
In
this
project,
the
medicinal
components
of
chicory
were
further
investigated
for
activity
against
Trypanosoma
brucei,
Herpes
Simplex
Virus
Type-‐I,
and
inflammation.
Utilizing
a
bioassay-‐guided
fractionation
approach,
two
compounds,
8-‐deoxylactucin
and
lactupicrin,
were
isolated
and
identified
as
the
active
components
against
T.
brucei.
A
third
compound
(11,13-‐dihydrolactucin)
was
also
identified
but
not
isolated,
and
thus
no
conclusions
could
be
made
on
its
activity.