Synthesis and Evaluation of Polyasparatate Peptoid Polymers against Pseudomonas aeruginosa

Abstract

Polyaspartic acid and its derivatives, such as peptoid polymers, have garnered attention for their potential as antimicrobial agents due to their biocompatibility and structural versatility. This research project delves into the synthesis and evaluation of novel polyaspartate peptoid polymers, aiming to unveil their antimicrobial potential and shed light on their structure-activity relationships. The primary objective is to explore the impact of these novel polyaspartate peptoid polymers on Pseudomonas aeruginosa biofilms, investigating their potential as disruptors or inhibitors of biofilm formation. Furthermore, an examination of their susceptibility to proteases aims to determine their stability and potential application as protease substrates. Central to this investigation is the comparison between peptide versions of polyaspartic acid and the peptoid versions being synthesized. Elucidating the differences in their structures and properties will provide valuable insights into the tailored design of antimicrobial materials. The study's methodology involves synthesizing polyaspartate peptoid polymers of varying lengths to evaluate their efficacy against microbial growth and biofilm formation. By systematically varying the length of these polymers, the aim is to discern the relationship between polymer structure and antimicrobial activity, thereby contributing to the understanding of structure-function correlations in these materials