Isolation of apigenin from Antirrhinum majas
| dc.contributor.author | Allen, Shannon | |
| dc.date.accessioned | 2015-12-09T18:39:09Z | |
| dc.date.available | 2015-12-09T18:39:09Z | |
| dc.date.issued | 2015-12 | |
| dc.description.abstract | Many adults have been exposed to Herpes Simplex Virus Type 1 (HSV-‐1), which manifests as a painful cold sore. Currently, Acyclovir is the most commonly used drug to reduce the number and severity of HSV-‐1 outbreaks. The purpose of this research is to isolate an anti-‐viral compound from plant material that will treat HSV-‐1. Snapdragon (A. majus) was selected for extractions due to the anti-‐viral activity found in its crude plant material. Detailed bioassay guided fractionation of A. majus plant material resulted in identification of a compound called apigenin. Although apigenin is a common flavonoid with documented anti-‐viral activity, it has not been reported previously in A. majus. A published comparison of EC50 values for apigenin and Acyclovir indicates that apigenin could potentially be a replacement drug for the treatment of herpes simplex viruses in Acyclovir-‐resistant patients | en_US |
| dc.identifier.uri | http://jewlscholar.mtsu.edu/handle/mtsu/4706 | |
| dc.publisher | University Honors College, Middle Tennessee Staate University | en_US |
| dc.subject | natural product isolation | en_US |
| dc.subject | bio-assay guided fractionalism | en_US |
| dc.subject | flavanoid | en_US |
| dc.subject | snapdragon | en_US |
| dc.title | Isolation of apigenin from Antirrhinum majas | en_US |
| dc.type | Thesis | en_US |