Assessment of Anti Herpes Simplex Virus Type 1 Activity in Bidens biternata and Mangifera persiciformis
Assessment of Anti Herpes Simplex Virus Type 1 Activity in Bidens biternata and Mangifera persiciformis
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Date
2017-05
Authors
Tabotabo, Darcy
Journal Title
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Publisher
University Honors College, Middle Tennessee State University
Abstract
The disease known as herpes, caused by herpes simplex virus type 1 (HSV), is a common
infection resulting in lesions on the mouth or genitals. At least half of the population of
the United States has experienced infection by HSV. There is presently no preventative
vaccine for HSV and resistance to acyclovir, the only currently available therapy, is
increasing. This signals a need to find other chemotherapeutic agents to use in treatment.
This research evaluated extracts from two plants, Bidens biternata and Mangifera
persiciformis, both used in traditional Chinese medicine, for potential anti herpes
properties in a cell culture system. Both of these plants have shown high anti herpes
activity. Bidens biternata showed 6% cytotoxicity from its most active fraction; however,
this fraction failed to reliably inhibit HSV. We report an unknown isolated compound
from M. persiciformis that has shown nearly 90% virus inhibition with 6% cytotoxicity at
50 μg/mL. This promising compound will be evaluated for structural identification in a
future project.
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Description
Keywords
anti-herpes,
traditional Chine medicine