Cytopathic Effects of Aurones in a Mouse Cell Line L929 Cells

Abstract

Cancer has been one of the major concerns in healthcare. The disease is most lethal when it becomes metastatic, Fibroblast aids in this process through microenvironment formation. The extracellular matrix around the cancer site is remodeled, enhancing cancer progression. Therefore, there has been research ongoing to find compounds with medicinal implications by targeting the fibroblast and restraining cancer site progression. A potential compound is aurones, that are naturally found in the pigmentation of yellow rocket snapdragon flowers. Due to the versatility of aurones for many treatments, the compound has been chemically modified and screened on TNFinduced L929 cells for their effects on cytotoxicity. A cell viability test was used to gather data on the effect of aurones and the ANOVA and posthoc Dunnett test the following three groups were categorized: death inhibitory, death enhancing, and neutral. The aurones 1 & 2 were death inhibitory, while 4, 5, & 8 were found to be neutral, and the rest had death-enhancing effects. Based on the categories further studies will be done on the specific pathway affected by the aurones.