Deletion of Folate Biosynthesis Gene, ABZ1, Produces Transient Life-Span Extension in Budding Yeast

Abstract

Folate, also known as vitamin B9, is essential for cellular processes in many organisms, including humans and nematodes. A prior study found that reduced folate levels led to an increase in nematode lifespan. The purpose of this study was to determine if folate biosynthesis mutations could also affect lifespan in the model organism, budding yeast. Yeast have five folate biosynthesis genes, one