Cytopathic Effects of Aurones in a Mouse Cell Line L929 Cells
Cytopathic Effects of Aurones in a Mouse Cell Line L929 Cells
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Date
2023-12
Authors
Patel, Shivam
Journal Title
Journal ISSN
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Publisher
University Honors College, Middle Tennessee State University
Abstract
Cancer has been one of the major concerns in healthcare. The disease is most
lethal when it becomes metastatic, Fibroblast aids in this process through
microenvironment formation. The extracellular matrix around the cancer site is
remodeled, enhancing cancer progression. Therefore, there has been research ongoing to
find compounds with medicinal implications by targeting the fibroblast and restraining
cancer site progression. A potential compound is aurones, that are naturally found in the
pigmentation of yellow rocket snapdragon flowers. Due to the versatility of aurones for
many treatments, the compound has been chemically modified and screened on TNFinduced
L929 cells for their effects on cytotoxicity. A cell viability test was used to gather
data on the effect of aurones and the ANOVA and posthoc Dunnett test the following
three groups were categorized: death inhibitory, death enhancing, and neutral. The
aurones 1 & 2 were death inhibitory, while 4, 5, & 8 were found to be neutral, and the
rest had death-enhancing effects. Based on the categories further studies will be done on
the specific pathway affected by the aurones.